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Open Access Green as soon as Postprint is submitted to ZB.
Cardiolipin signaling mechanisms: Collapse of asymmetry and oxidation.
Antioxid. Redox Signal. 22, 1667-1680 (2015)
SIGNIFICANCE: An ancient anionic phospholipid, cardiolipin, ubiquitously present in prokaryotic and eukaryotic membranes, is essential for several structural and functional purposes. RECENT ADVANCES: The emerging role of cardiolipins in signaling has become the focus of many studies. CRITICAL ISSUES: In this work, we describe two major pathways through which mitochondrial cardiolipins may fulfill the signaling functions via utilization of their: i) asymmetric distribution across membranes and translocations leading to the surface externalization, and ii) ability to undergo oxidation reactions to yield the signature products recognizable by the executionary machinery of cells. FUTURE DIRECTIONS: We present a concept that cardiolipins and their oxidation/hydrolysis products constitute a rich communication language utilized by mitochondria of eukaryotic cells for diversified regulation of cell physiology and metabolism as well as for inter-cellular interactions.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1523-0864
e-ISSN
1557-7716
Journal
Antioxidants & Redox Signaling
Quellenangaben
Volume: 22,
Issue: 18,
Pages: 1667-1680
Publisher
Mary Ann Liebert
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)