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Spatially resolved quantification of Gadolinium(III)-based magnetic resonance agents in tissue by MALDI imaging mass spectrometry after in vivo MRI.
Angew. Chem.-Int. Edit. 54, 4279-4283 (2015)
Gadolinium(III)-based contrast agents improve the sensitivity and specificity of magnetic resonance imaging (MRI), especially when targeted contrast agents are applied. Because of nonlinear correlation between the contrast agent concentration in tissue and the MRI signal obtained in vivo, quantification of certain biological or pathophysiological processes by MRI remains a challenge. Up to now, no technology has been able to provide a spatially resolved quantification of MRI agents directly within the tissue, which would allow a more precise verification of in vivo imaging results. MALDI imaging mass spectrometry for spatially resolved in situ quantification of gadolinium(III) agents, in correlation to in vivo MRI, were evaluated. Enhanced kinetics of Gadofluorine M were determined dynamically over time in a mouse model of myocardial infarction. MALDI imaging was able to corroborate the in vivo imaging MRI signals and enabled in situ quantification of the gadolinium probe with high spatial resolution.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Biochemistry ; Gadolinium ; Imaging Agents ; Kinetics ; Mass Spectrometry; Contrast Agents; Atherosclerotic Plaque; High-resolution; Ionization; Complexes
ISSN (print) / ISBN
1433-7851
e-ISSN
1521-3773
Quellenangaben
Volume: 54,
Issue: 14,
Pages: 4279-4283
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
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Reviewing status
Peer reviewed