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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Eur. J. Cell Biol. 87, 197-209 (2008)
Islet cell autoantigen of 69kDa (ICA69) is a small GTPase-binding protein of unknown function. ICA69 is enriched in the Golgi complex and its N-terminal half contains a BAR domain, a module that can bind/bend membranes and interacts with phospholipids. Here we show that in insulinoma INS-1 cells ICA69 binds to the small GTPase Rab2, which regulates the transport of COPI vesicles between the endoplasmic reticulum and the Golgi complex. Rab2 binds to ICA69 in a GTP-dependent fashion and recruits it to membranes. Over-expression of either Rab2 or ICA69 in INS-1 cells results in a phenotype characterized by: (i) impaired anterograde transport of the secretory granule protein precursors pro-ICA512 and chromogranin A; (ii) reduction of stimulated insulin secretion. Taken together, these data identify ICA69 as a novel Rab2 effector and point to its role in regulating the early transport of insulin secretory granule proteins.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0171-9335
e-ISSN
1618-1298
Journal
European Journal of Cell Biology
Quellenangaben
Volume: 87,
Issue: 4,
Pages: 197-209
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)