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Open Access Green as soon as Postprint is submitted to ZB.
Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity.
Ann. Neurol. 55, 286-290 (2004)
Stiff-Man syndrome (SMS) is a rare disease of the central nervous system characterized by chronic muscle rigidity and autoimmunity directed against synaptic antigens. In a subset of patients, generally positive for antiamphiphysin autoantibodies, SMS has an autoimmune paraneoplastic origin. Amphiphysin isoforms are expressed at high levels in brain and skeletal muscle and often are overexpressed in breast cancer. We report here the occurrence of rhabdomyolysis in a patient with SMS, breast cancer, and antibodies that recognize both brain and muscle amphiphysin isoforms. Immunotherapy induced a remission of both rhabdomyolysis and SMS symptoms. Autoimmune rhabdomyolysis may represent a paraneoplastic complication of cancer patients with amphiphysin autoimmunity.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2004
HGF-reported in Year
0
ISSN (print) / ISBN
0364-5134
e-ISSN
1531-8249
Journal
Annals of Neurology
Quellenangaben
Volume: 55,
Issue: 2,
Pages: 286-290
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
14755734
Erfassungsdatum
2004-12-31