PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Perez, L.* ; Wolf, K. ; Hennig, F.* ; Penell, J.* ; Basagana, X.* ; Aguilera, I.* ; Agis, D.* ; Beelen, R.* ; Brunekreef, B.* ; Cyrys, J.* ; Fuks, K.B.* ; Adam, M.* ; Baldassare, D.* ; Cirach, M.* ; Elosua, R.* ; Dratva, J.* ; Hampel, R. ; Koenig, W.* ; Marrugat, J.* ; de Faire, U.* ; Pershagen, G.* ; Probst-Hensch, N.M.* ; de Nazelle, A.* ; Nieuwenhuijsen, M.J.* ; Rathmann, W.* ; Rivera, M.* ; Seissler, J. ; Schindler, C.* ; Thierry, J.* ; Hoffmann, B.* ; Peters, A. ; Künzli, N.*

Air pollution and atherosclerosis: A cross-sectional analysis of four European cohort studies in the ESCAPE study.

Environ. Health Perspect. 123, 597-605 (2015)
Publ. Version/Full Text DOI PMC
Open Access Gold
BACKGROUND: In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a pre-clinical marker of atherosclerosis. METHODS: Individually assigned levels of NO2, NOx, PM2.5, absorbance of PM2.5 (PM2.5abs), PM10, PMcoarse, and two indicators of residential proximity to highly trafficked roads were obtained under a standard exposure protocol (European Study of Cohorts for Air Pollution effects-ESCAPE study) in the Stockholm area (Sweden), the Ausburg and Ruhr area (Germany) and the Girona area (Spain). We used linear regression and meta-analyses to examine the association between long-term exposure to air pollution and CIMT. RESULTS: The meta-analysis with 9183 individuals resulted in an estimated increase in CIMT (geometric mean) of 0.72% (95% Confidence Interval [CI]: -0.65%, 2.10%) per 5 µg/m(3) increase in PM2.5 and 0.42% (95% CI: -0.46%, 1.30%) per 10(-5)/m increase in PM2.5abs. Living in proximity to high traffic was also positively but not significantly associated with CIMT. Meta-analytic estimates for other pollutants were inconsistent. Results were similar across different adjustment sets and sensitivity analyses. In an extended meta-analysis for PM2.5 with three other previously published studies, a 0.78% (95% CI: -0.18%, 1.75%) increase in CIMT was estimated for a 5 µg/m(3) contrast in PM2.5. CONCLUSIONS: Using a standardized exposure and analytical protocol in four European cohorts, cross-sectional associations between CIMT and the eight ESCAPE markers of long-term residential air pollution exposure did not reach statistical significance. The additional meta-analysis of CIMT and PM2.5 across all published studies also was positive but not significant.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.977
2.255
42
56
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Intima-media Thickness; Use Regression-models; Long-term Exposure; Particulate Matter; Subclinical Atherosclerosis; Carotid-artery; Oxidative Stress; Young-adults; No2; Metaanalysis
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Journal Environmental Health Perspectives
Quellenangaben Volume: 123, Issue: 6, Pages: 597-605 Article Number: , Supplement: ,
Publisher Research Triangle Park
Publishing Place NC [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 30202 - Environmental Health
30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-001
G-521500-002
G-504000-004
PubMed ID 25625785
DOI 10.1289/ehp.1307711
WOS ID WOS:000357296200021
Erfassungsdatum 2015-02-20
[➜Report correction]