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In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb.
Nat. Commun. 6:6349 (2015)
Juxtaglomerular neurons (JGNs) of the mammalian olfactory bulb are generated throughout life. Their integration into the preexisting neural network, their differentiation and survival therein depend on sensory activity, but when and how these adult-born cells acquire responsiveness to sensory stimuli remains unknown. In vivo two-photon imaging of retrovirally labelled adult-born JGNs reveals that ~90% of the cells arrive at the glomerular layer after day post injection (DPI) 7. After arrival, adult-born JGNs are still migrating, but at DPI 9, 52% of them have odour-evoked Ca(2+) signals. Their odourant sensitivity closely resembles that of the parent glomerulus and surrounding JGNs, and their spontaneous and odour-evoked spiking is similar to that of their resident neighbours. Our data reveal a remarkably rapid functional integration of adult-born cells into the preexisting neural network. The mature pattern of odour-evoked responses of these cells strongly contrasts with their molecular phenotype, which is typical of immature, migrating neuroblasts.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Granule Cells; Long-term; Synaptic Integration; Generated Neurons; Newborn Neurons; Mammalian Brain; Critical Period; Sensory Input; Neurogenesis; Interneurons
Language
english
Publication Year
2015
HGF-reported in Year
2015
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 6,
Article Number: 6349
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500800-001
PubMed ID
25695931
WOS ID
WOS:000350292400007
Scopus ID
84923372636
Erfassungsdatum
2015-02-21