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Hüttl, R.E. ; Luxenhofer, G. ; Bianchi, E. ; Haupt, C. ; Joshi, R.* ; Prochiantz, A.* ; Huber, A.B.

Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.

PLoS ONE 10:e0118505 (2015)
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Engrailed-1 (En1) is expressed in the ventral ectoderm of the developing limb where it plays an instructive role in the dorsal-ventral patterning of the forelimb. Besides its well-described role as a transcription factor in regulating gene expression through its DNA-binding domain, En1 may also be secreted to form an extracellular gradient, and directly impact on the formation of the retinotectal map. We show here that absence of En1 causes mispatterning of the forelimb and thus defects in the dorsal-ventral pathfinding choice of motor axons in vivo. In addition, En1 but not En2 also has a direct and specific repulsive effect on motor axons of the lateral aspect of the lateral motor column (LMC) but not on medial LMC projections. Moreover, an ectopic dorsal source of En1 pushes lateral LMC axons to the ventral limb in vivo. Thus, En1 controls the establishment of limb innervation through two distinct molecular mechanisms.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Motor Axon Guidance; Vertebrate Limb; Mouse Limb; Homeodomain Protein; Visual-cortex; Retinal Axons; Mutant Mice; Neurons; Differentiation; Expression
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 10, Issue: 2, Pages: , Article Number: e0118505 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500592-001
PubMed ID 25710467
DOI 10.1371/journal.pone.0118505
WOS ID WOS:000350683900060
Scopus ID 84923338371
Erfassungsdatum 2015-02-26
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