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Monti, P.* ; Heninger, A.K.* ; Bonifacio, E.*

Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus.

Curr. Diab. Rep. 9, 113-118 (2009)
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Open Access Green as soon as Postprint is submitted to ZB.
Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulin-producing beta cells is still poorly understood. T cells potentially able to recognize and destroy beta cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2009
HGF-reported in Year 0
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Journal Current Diabetes Reports
Quellenangaben Volume: 9, Issue: 2, Pages: 113-118 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
PubMed ID 19323955
Erfassungsdatum 2009-12-31
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