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Coskun, Ü.* ; Simons, K.*

Membrane rafting: from apical sorting to phase segregation.

FEBS Lett. 584, 1685-1693 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
In this review we describe the history of the development of the raft concept for membrane sub-compartmentalization. From its early beginnings as a mechanism for apical sorting in epithelial cells the concept has evolved to a general principle for membrane organisation. After a shaky start with crude methodology based on detergent extraction the field has become increasingly sophisticated, employing a host of different methods that support the existence of dynamic raft domains in membranes. These are composed of fluctuating nanoscale assemblies of sphingolipid, cholesterol and proteins that can be stabilized to coalesce, forming platforms that function in membrane signalling and trafficking.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2010
HGF-reported in Year 0
ISSN (print) / ISBN 0014-5793
e-ISSN 1873-3468
Journal FEBS Letters
Quellenangaben Volume: 584, Issue: 9, Pages: 1685-1693 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
PubMed ID 20036659
DOI 10.1016/j.febslet.2009.12.043
Erfassungsdatum 2010-12-31
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