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Open Access Green as soon as Postprint is submitted to ZB.
Cholesterol modulates glycolipid conformation and receptor activity.
Nat. Chem. Biol. 7, 260-262 (2011)
We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2011
HGF-reported in Year
0
ISSN (print) / ISBN
1552-4450
e-ISSN
1552-4469
Journal
Nature Chemical Biology
Quellenangaben
Volume: 7,
Issue: 5,
Pages: 260-262
Publisher
Nature Publishing Group
Publishing Place
Basingstoke
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
21460830
Erfassungsdatum
2011-12-31