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Calzolari, F. ; Michel, J. ; Baumgart, E.V. ; Theis, F.J. ; Götz, M. ; Ninkovic, J.

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.

Nat. Neurosci. 18, 490-492 (2015)

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Open Access Green as soon as Postprint is submitted to ZB.

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We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 1097-6256

e-ISSN 1546-1726

Journal Nature Neuroscience

Quellenangaben Volume: 18, Issue: 4, Pages: 490-492

Publisher Nature Publishing Group

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Stem Cell Research (ISF)
Institute of Computational Biology (ICB)