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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Proliferative and survival effects of PUMA promote angiogenesis.
Cell Rep. 2, 1272-1285 (2012)
The p53 upregulated modulator of apoptosis (PUMA) is known as an essential apoptosis inducer. Here, we report the seemingly paradoxical finding that PUMA is a proangiogenic factor critically required for the proliferation and survival of vascular and microglia cells. Strikingly, Puma deficiency by genetic deletion or small hairpin RNA knockdown inhibited developmental and pathological angiogenesis and reduced microglia numbers in vivo, whereas Puma gene delivery increased angiogenesis and cell survival. Mechanistically, we revealed that PUMA plays a critical role in regulating autophagy by modulating Erk activation and intracellular calcium level. Our findings revealed an unexpected function of PUMA in promoting angiogenesis and warrant more careful investigations into the therapeutic potential of PUMA in treating cancer and degenerative diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2012
HGF-reported in Year
0
ISSN (print) / ISBN
2211-1247
e-ISSN
2211-1247
Journal
Cell Reports
Quellenangaben
Volume: 2,
Issue: 5,
Pages: 1272-1285
Publisher
Cell Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
23122957
Erfassungsdatum
2012-12-31