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Vassilopoulos, A.* ; Deng, C.X.* ; Chavakis, T.*

Crosstalk between the DNA damage response, histone modifications and neovascularisation.

Int. J. Biochem. Cell Biol. 42, 193-197 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2010
HGF-reported in Year 0
ISSN (print) / ISBN 1357-2725
e-ISSN 1878-5875
Journal International Journal of Biochemistry & Cell Biology, The
Quellenangaben Volume: 42, Issue: 2, Pages: 193-197 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
PubMed ID 19945543
DOI 10.1016/j.biocel.2009.11.020
Erfassungsdatum 2010-12-31
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