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Open Access Green as soon as Postprint is submitted to ZB.
Novel aspects in the regulation of the leukocyte adhesion cascade.
Thromb. Haemost. 102, 191-197 (2009)
Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium including leukocyte rolling, adhesion and transendothelial migration. Leukocyte-endothelial interactions are mediated by tightly regulated binding interactions between adhesion receptors on both cells. In this regard, leukocyte adhesion onto the endothelium is governed by leukocyte integrins and their endothelial counter-receptors of the immunoglobulin superfamily. The present review will focus on novel aspects with respect to the modulation of the leukocyte adhesion cascade.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2009
HGF-reported in Year
0
ISSN (print) / ISBN
0340-6245
Journal
Thrombosis and Haemostasis
Quellenangaben
Volume: 102,
Issue: 2,
Pages: 191-197
Publisher
Schattauer
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
19652868
Erfassungsdatum
2009-12-31