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Levy, W. ; Henkelmann, B. ; Bernhöft, S. ; Bovee, T.* ; Buegger, F. ; Jakobi, G. ; Kirchner, M. ; Bassan, R.* ; Kräuchi, N.* ; Moche, W.* ; Offenthaler, I.* ; Simoncic, P.* ; Weiss, P.* ; Schramm, K.-W.

Persistent aryl hydrocarbon receptor inducers increase with altitude, and estrogen-like disrupters are low in soils of the Alps.

Environ. Sci. Pollut. Res. 18, 99-110 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Soil samples from remote Alpine areas were analyzed for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and polychlorinated biphenyls by high-resolution gas chromatography/high-resolution gas spectrometry. Additionally, the EROD micro-assay and a genetically modified yeast estrogen bioassay were carried out to determine persistent aryl hydrocarbon receptors (AhR) and estrogen receptors (ER) agonists, respectively. Regarding the AhR agonists, the toxicity equivalents of analytical and EROD determined values were compared, targeting both altitude of samples and their soil organic content. The ratio between bioassay derived equivalents and analytical determinations suggested no significant contribution of unknown AhR inducers in these sampling sites and some antagonism in soils with relatively high PCB loading. More CYP1A1 expression was induced at the highest sites or about 1400-1500 m a.s.l. along the altitude profiles. Surprisingly, no clear tendencies with the soil organic content were found for dioxin-like compounds. Mean values obtained in the present study were for ER agonists, 0.37 +/- 0.12 pg 17ss-estradiol EQ g(-1) dry soil and 6.1 +/- 4.2 pg TCDD-EQ g(-1) dry soil for AhR agonists. CONCLUSION: Low bioassay responses with a higher relative amount of AhR inducers than ER disrupters were detected, indicating the higher abundance of persistent dioxin-like than estrogen-like compounds in these forested mountainous areas.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Micro-EROD bioassay; Estrogenicity; Genetically modified yeast bioassay; Humus soil; TEQ values; Altitude profiles; PCB
ISSN (print) / ISBN 0944-1344
e-ISSN 1614-7499
Journal Environmental Science and Pollution Research
Quellenangaben Volume: 18, Issue: 1, Pages: 99-110 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Ecological Chemistry (IOEC)
Institute of Soil Ecology (IBOE)
Cooperation Group Comprehensive Molecular Analytics (CMA)