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Levy, W. ; Henkelmann, B. ; Bernhöft, S. ; Bovee, T.* ; Buegger, F. ; Jakobi, G. ; Kirchner, M. ; Bassan, R.* ; Kräuchi, N.* ; Moche, W.* ; Offenthaler, I.* ; Simoncic, P.* ; Weiss, P.* ; Schramm, K.-W.

Persistent aryl hydrocarbon receptor inducers increase with altitude, and estrogen-like disrupters are low in soils of the Alps.

Environ. Sci. Pollut. Res. 18, 99-110 (2011)

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BACKGROUND: Soil samples from remote Alpine areas were analyzed for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and polychlorinated biphenyls by high-resolution gas chromatography/high-resolution gas spectrometry. Additionally, the EROD micro-assay and a genetically modified yeast estrogen bioassay were carried out to determine persistent aryl hydrocarbon receptors (AhR) and estrogen receptors (ER) agonists, respectively. Regarding the AhR agonists, the toxicity equivalents of analytical and EROD determined values were compared, targeting both altitude of samples and their soil organic content. The ratio between bioassay derived equivalents and analytical determinations suggested no significant contribution of unknown AhR inducers in these sampling sites and some antagonism in soils with relatively high PCB loading. More CYP1A1 expression was induced at the highest sites or about 1400-1500 m a.s.l. along the altitude profiles. Surprisingly, no clear tendencies with the soil organic content were found for dioxin-like compounds. Mean values obtained in the present study were for ER agonists, 0.37 +/- 0.12 pg 17ss-estradiol EQ g(-1) dry soil and 6.1 +/- 4.2 pg TCDD-EQ g(-1) dry soil for AhR agonists. CONCLUSION: Low bioassay responses with a higher relative amount of AhR inducers than ER disrupters were detected, indicating the higher abundance of persistent dioxin-like than estrogen-like compounds in these forested mountainous areas.

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