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Open Access Green as soon as Postprint is submitted to ZB.
Leukocyte trans-endothelial migration: JAMs add new pieces to the puzzle.
Thromb. Haemost. 89, 13-17 (2003)
The molecular details of leukocyte transmigration through the endothelial barrier (also called diapedesis), which is the final step of leukocyte extravasation from the circulation to a given site of inflammation, are by far not well understood. The present review will focus on the different mechanisms potentially involved in leukocyte trans-endothelial migration. Both homophilic and heterophilic interactions between leukocyte and endothelial cell receptors will be covered, with a particular focus on the growing gene family of junctional adhesion molecules (JAM). Deciphering their mechanisms of interaction will also allow to unravel novel strategies for therapeutic intervention in inflammatory or atherothrombotic diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2003
HGF-reported in Year
0
ISSN (print) / ISBN
0340-6245
Journal
Thrombosis and Haemostasis
Quellenangaben
Volume: 89,
Issue: 1,
Pages: 13-17
Publisher
Schattauer
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
12540948
Erfassungsdatum
2003-12-31