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Serum bilirubin levels, UGT1A1 polymorphisms and risk for coronary artery disease.
Exp. Gerontol. 43, 1102-1107 (2008)
Low levels of the antioxidative serum bilirubin are associated with vascular aging and an increased risk for coronary artery disease (CAD). UGT1A1 is the major gene influencing bilirubin concentrations. Therefore, we investigated an association of bilirubin levels and two polymorphisms in the promoter of UGT1A1 I (-53(TA-repeat) polymorphism and T-3279C) in 477 patients with premature, familial CAD and 619 age-and sex-matched controls. Bilirubin concentrations were significantly lower in cases than in controls (0.62 +/- 0.36 vs. 0.76 +/- 0.41 mg/dl for men, p = 1.2 x 10(-10) and 0.42 +/- 0.29 vs. 0.55 +/- 0.23 mg/dl, p = 1.9 x 10(-9) for women). Both polymorphisms showed a strong association with bilirubin levels with higher levels for homozygote carriers of the minor allele. These associations were most pronounced in male controls and patients (p = 5.9 x 10(-26) and p = 3.4 x 10(-16), respectively, for the -53(TA-repeat) polymorphism). Logistic regression analysis revealed low bilirubin levels but not the UGT1A1 polymorphisms to be significantly associated with CAD: OR (95% CI) 0.90 (0.86-0.94), p = 2.6 x 10(-6) for men and 0.77 (0.68-0.87), p = 3.2 x 10(-5) for women, respectively for each 0.1 mg/dl increase of bilirubin. These results indicate that it is rather decreased bilirubin levels in general than the changes in the genetic variation of this gene that increase the risk for CAD.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bilirubin; Coronary artery disease; UGT1A1; Association study; Polymorphism
Language
english
Publication Year
2008
HGF-reported in Year
2008
ISSN (print) / ISBN
0531-5565
e-ISSN
0531-5565
Journal
Experimental Gerontology
Quellenangaben
Volume: 43,
Issue: 12,
Pages: 1102-1107
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30503 - Chronic Diseases of the Lung and Allergies
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-503900-001
Scopus ID
56349113665
Erfassungsdatum
2008-12-31