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Attia, A.B.E.* ; Balasundaram, G.* ; Driessen, W.H.P. ; Ntziachristos, V. ; Olivo, M.*

Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging.

Biomed. Opt. Express 6, 591-598 (2015)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
There is a need for contrast agents for non-invasive diagnostic imaging of tumors. Herein, Multispectral Optoacoustic Tomography (MSOT) was employed to evaluate phthalocyanines commonly used in photodynamic therapy as photoacoustic contrast agents. We studied the photoacoustic activity of three water-soluble phthalocyanine photosensitizers: phthalocyanine tetrasulfonic acid (PcS4), Zn(II) phthalocyanine tetrasulfonic acid (ZnPcS4) and Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) in phantom and in tumor-bearing mice to investigate the biodistribution and fate of the phthalocyanines in the biological tissues. PcS4 was observed to grant good contrast between the different reticuloendothelial organs and accumulate in the tumor within an hour of post-administration. ZnPcS4 and AlPcS4 offered little contrast in photoacoustic signals between the organs. PcS4 is a promising photoacoustic contrast agent and can be exploited as a photodiagnostic agent.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords (110.4234) Multispectral And Hyperspectral Imaging ; (110.5125) Photoacoustics ; (160.1050) Acousto-optical Materials ; (170.3880) Medical And Biological Imaging ; (170.5120) Photoacoustic Imaging ; (170.6930) Tissue; Zinc Phthalocyanine; Fluorescence Kinetics; Photodynamic Therapy; Tomography; Model
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Journal Biomedical Optics Express
Quellenangaben Volume: 6, Issue: 2, Pages: 591-598 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Publishing Place Washington
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)