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Knowlton, S.M.* ; Sadasivam, M. ; Tasoglu, S.*

Microfluidics for sperm research.

Trends Biotechnol. 33, 221-229 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
One in six couples of reproductive age worldwide are affected at least once by some form of infertility. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are widely-available assisted reproductive technologies (ART). The identification and isolation of the most-motile sperm with DNA integrity are essential to IVF and ICSI, ultimately affecting treatment consequences and the health of offspring. Recently, microfluidic technologies been developed to sort sperm according to sperm morphology, motility, DNA integrity, and functionality for IVF techniques. There have also been emerging applications in wildlife conservation, high-throughput single-sperm genomics, sperm-driven robotics, and in-home fertility testing. We review a broad range of studies applying the principles of microfluidics to sperm research.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Microfluidics ; Point-of-care ; Sperm Genomics ; Sperm Sorting For Infertility ; Sperm-driven Robotics ; Wildlife Conservation; Single-cell Analysis; On-chip; Dna Integrity; Motile Sperm; Device; Chemotaxis; Health; Future; Technologies; Trajectories
ISSN (print) / ISBN 0167-7799
e-ISSN 1879-3096
Quellenangaben Volume: 33, Issue: 4, Pages: 221-229 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed