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Open Access Green as soon as Postprint is submitted to ZB.
ArRAnging the hindbrain.
Trends Neurosci. 25, 61-64 (2002)
The retinoic acid (RA)-dependent mechanisms that orchestrate the development of the hindbrain have been the focus of intense studies over the last decade. A wide range of model systems and experimental approaches have been used to provide important insights into hindbrain patterning. A recent paper could help to unify seemingly disparate observations across species and experimental approaches. Specification of the entire caudal hindbrain is fully dependent on retinoic acid, and specification of individual rhombomeres (r) follows a strict rostrocaudal sequence at precise developmental time windows. Progressively higher RA signalling is necessary for assigning more posterior territories. Complete RA deficiency results in the caudal hindbrain assuming an r4-like identity, which is postulated to be the hindbrain ground state.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
0166-2236
e-ISSN
1878-108X
Journal
Trends in Neurosciences
Quellenangaben
Volume: 25,
Issue: 2,
Pages: 61-64
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502600-003
PubMed ID
11814548
Erfassungsdatum
2004-12-31