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Open Access Green as soon as Postprint is submitted to ZB.
Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter.
Mol. Cell. Biol. 13, 4784-4792 (1993)
Two avian genes encoding essential steps in the purine nucleotide biosynthetic pathway are transcribed divergently from a bidirectional promoter element. The bidirectional promoter, embedded in a CpG island, directs coexpression of GPAT and AIRC genes from distinct transcriptional start sites 229 bp apart. The bidirectional promoter can be divided in half, with each half retaining partial activity towards the cognate gene. GPAT and AIRC genes encode the enzymes that catalyze step 1 and steps 6 plus 7, respectively, in the de novo purine biosynthetic pathway. This is the first report of genes coding for structurally unrelated enzymes of the same pathway that are tightly linked and transcribed divergently from a bidirectional promoter. This arrangement has the potential to provide for regulated coexpression comparable to that in a prokaryotic operon.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0270-7306
e-ISSN
1098-5549
Journal
Molecular and Cellular Biology
Quellenangaben
Volume: 13,
Issue: 8,
Pages: 4784-4792
Publisher
American Society for Microbiology (ASM)
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)