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Orphan receptor IL-17RD regulates toll-like receptor signalling via SEFIR/TIR interactions.
Nat. Commun. 6:6669 (2015)
Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 receptor D (IL-17RD) in negatively regulating Toll-like receptor (TLR)-induced responses. Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock. We demonstrate that the intracellular Sef/IL-17R (SEFIR) domain of IL-17RD targets TIR adaptor proteins to inhibit TLR downstream signalling thus revealing a paradigm involving cross-regulation of members of the IL-17R and TLR families.
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Times Cited
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11.470
3.052
24
29
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Nf-kappa-b; Domain-containing Adapter; Cutting Edge; Drosophila Toll; Activation; Pathway; Sef; Protein; Kinase; Family
Language
english
Publication Year
2015
HGF-reported in Year
2015
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 6,
Article Number: 6669
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-001
PubMed ID
25808990
WOS ID
WOS:000353042400003
Scopus ID
84925834283
Erfassungsdatum
2015-03-28