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Open Access Green as soon as Postprint is submitted to ZB.
DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
Exp. Cell Res. 334, 146-159 (2015)
PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs. Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex. DDX27 interacts with the PeBoW-complex via an evolutionary conserved FxF motif in the N-terminal domain and is recruited to the nucleolus via its basic C-terminal domain. This recruitment is RNA-dependent and occurs independently of the PeBoW-complex. Interestingly, knockdown of DDX27, but not of Pes1, induces the accumulation of an extended form of the primary 47S rRNA. We conclude that DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dead-box Helicase ; Fxf Motif ; Nucleolus ; Pebow-complex ; Rrna Processing; Cell-proliferation; Polymerase-i; Terminal Domain; Biogenesis; Protein; Yeast; Transcription; Bop1; Wdr12; Pes1
Language
english
Publication Year
2015
HGF-reported in Year
2015
ISSN (print) / ISBN
1090-2422
e-ISSN
0014-4827
Journal
Experimental Cell Research
Quellenangaben
Volume: 334,
Issue: 1,
Pages: 146-159
Publisher
Academic Press
Publishing Place
Orlando, Fla.
Reviewing status
Peer reviewed
Institute(s)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Institute of Molecular Immunology (IMI)
Institute of Molecular Immunology (IMI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501400-006
G-501490-001
G-501793-001
G-501490-001
G-501793-001
PubMed ID
25825154
WOS ID
WOS:000354911100017
Scopus ID
84929267558
Scopus ID
84926169814
Erfassungsdatum
2015-04-02