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Colak, D. ; Mori, T. ; Brill, M.S. ; Pfeifer, A.* ; Falk, S.* ; Deng, C.* ; Monteiro, R.* ; Mummery, C.* ; Sommer, L.* ; Götz, M.

Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.

J. Neurosci. 28, 434-445 (2008)
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Open Access Green as soon as Postprint is submitted to ZB.
In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. Transplantation experiments further verified the cell-autonomous nature of this phenotype. Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis
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Publication type Article: Journal article
Document type Scientific Article
Keywords neural stem cells; Olig2; Dlx2; neurogenesis; oligodendrocytes; transplantation
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Journal Journal of Neuroscience
Quellenangaben Volume: 28, Issue: 2, Pages: 434-445 Article Number: , Supplement: ,
Publisher Society for Neuroscience
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
DOI 10.1523/JNEUROSCI.4374-07.2008
Scopus ID 38349070923
Erfassungsdatum 2008-08-21
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