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Open Access Green as soon as Postprint is submitted to ZB.
Making regulatory T cells with defined antigen specificity: Role in autoimmunity and cancer.
Immunol. Rev. 212, 163-169 (2006)
There is increasing evidence that agonist ligand presentation either intrathymically or extrathymically plays a crucial if not essential role in the generation of regulatory T cells (Tregs). Thus, it is possible to induce Tregs of any desired specificity in vivo. The same goal can be achieved in vitro by expanding antigen-specific CD4+ T cells and retrovirally transducing them. In contrast, in vitro expansion of Tregs is limited to antigens that have resulted in Treg generation in vivo. Antigen-specific Tregs can be used in cellular therapy with the goal to prevent autoimmune disease or even to interfere with established autoimmunity. The latter requires that the Tregs can suppress effector cells that have already caused harm, which is possible because of the antigen-dependent homing properties of Tregs, i.e. these cells can accumulate in antigen-draining lymph nodes and exit into inflamed tissue. Generally, the in vivo interference is dependent on cytokines such as transforming growth factor-beta and interleukin-10 that were dispensable in in vivo analysis of immunosuppression. The precise mechanisms of suppression remain enigmatic, however, but may be further elucidated by the molecular analysis of suppressed versus non-suppressed T cells.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0105-2896
e-ISSN
1600-065X
Journal
Immunological Reviews
Quellenangaben
Volume: 212,
Pages: 163-169
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)