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Berrios, C.* ; Jung, J.U.* ; Primi, B.* ; Wang, M.* ; Pedamallu, C.* ; Duke, F.* ; Marcelus, C.* ; Cheng, J.* ; Garcea, R.L.* ; Meyerson, M.* ; DeCaprio, J.A.* ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Henneberger, L. ; Hummel, M. ; Hummel, S. ; Knopff, A. ; Krause, S. ; Peplow, C. ; Pflüger, M. ; Roth, R. ; Schenkel, J. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.)

Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.

J. Virol. 89, 857-862 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Merkel Cell Polyomavirus; Small-t-antigen; African-green Monkey; Protein Phosphatase-2a; Genome; Identification; Transformation; Complexes; Disease; P53
ISSN (print) / ISBN 0022-538X
e-ISSN 1098-5514
Journal Journal of Virology
Quellenangaben Volume: 89, Issue: 1, Pages: 857-862 Article Number: , Supplement: ,
Publisher American Society for Microbiology (ASM)
Publishing Place Washington
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)