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Open Access Green as soon as Postprint is submitted to ZB.
The antioxidant requirement for plasma membrane repair in skeletal muscle.
Free Radical Biol. Med. 84, 246-253 (2015)
Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently inhibit repair. Here we provide three independent lines of evidence that VE is required for skeletal muscle myocyte plasma membrane repair in vivo. We also show that when another lipid-directed antioxidant, glutathione peroxidase 4 (Gpx4), is genetically deleted in mouse embryonic fibroblasts, repair fails catastrophically, unless cells are supplemented with VE. We conclude that lipid-directed antioxidant activity provided by VE, and possibly also Gpx4, is an essential component of the membrane repair mechanism in skeletal muscle. This work explains why VE is essential to muscle health and identifies VE as a requisite component of the plasma membrane repair mechanism in vivo.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Antioxidants ; Free Radicals ; Membrane Repair ; Skeletal Muscle ; Vitamin E; Hydroperoxide Glutathione-peroxidase; Frog Neuromuscular-junction; Vitamin-e Supplementation; Muscular-dystrophy; Oxidative Stress; E-deficiency; Exercise; Damage; Disruptions; Myopathy
ISSN (print) / ISBN
0891-5849
e-ISSN
1873-4596
Quellenangaben
Volume: 84,
Pages: 246-253
Publisher
Elsevier
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)