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Franquelim, H.G.* ; Linko, V.* ; Czogalla, A.* ; Dietz, H.* ; Schwille, P.*

Synthetic membrane curvature-inducing DNA origami scaffolds.

Biophys. J. 106:617a (2014)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Biological membranes are dynamic cellular barriers that suffer deformation and bending. Despite huge effort in identifying the general elements involved in membrane curvature, the physical-chemical basis of curvature induction is still poorly understood. In this work, we fill this gap by engineering a minimal curvature-inducing system. Due to its exclusive nanoengineering properties, DNA origami technology will be utilized to build minimal curvature-inducing scaffoldings. This state-of-the-art technology enables the folding of long strands of DNA into nano-objects with defined shapes by using sequence-specific short DNA staples.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2014
HGF-reported in Year 0
ISSN (print) / ISBN 0006-3495
e-ISSN 1542-0086
Journal Biophysical Journal
Quellenangaben Volume: 106, Issue: 2, Pages: , Article Number: 617a Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
DOI 10.1016/j.bpj.2013.11.3414
Erfassungsdatum 2014-12-31
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