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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Oral cyclosporine A - the current picture of its liposomal and other delivery systems.
Cell. Mol. Biol. Lett. 14, 139-152 (2009)
The discovery of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility and permeability) and the need to carefully monitor its levels in the blood. Current research is exploring various approaches, including those based on emulsions, microspheres, nanoparticles, and liposomes. Although progress has been made, none of the formulations is flawless. This review is a brief description of the main pharmaceutical systems and devices that have been described for the oral delivery of cyclosporine A in the context of the physicochemical properties of the drug and the character of its interactions with lipid membranes.
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Publication type
Article: Journal article
Document type
Review
Language
english
Publication Year
2009
HGF-reported in Year
0
ISSN (print) / ISBN
1425-8153
e-ISSN
1689-1392
Quellenangaben
Volume: 14,
Issue: 1,
Pages: 139-152
Publisher
Springer
Publishing Place
Warsaw : Versita ; Berlin ; Heidelberg
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
19005620
Erfassungsdatum
2009-12-31