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Boyman, O.* ; Kaegi, C.* ; Akdis, M.* ; Bavbek, S.* ; Bossios, A.* ; Chatzipetrou, A.* ; Eiwegger, T.* ; Firinu, D.* ; Harr, T.* ; Knol, E.* ; Matucci, A.* ; Palomares, O.* ; Schmidt-Weber, C.B. ; Simon, H.U.* ; Steiner, U.C.* ; Vultaggio, A.* ; Akdis, C.A.* ; Spertini, F.*

EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders.

Allergy 70, 727-754 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example a cytokine or receptor. In inflammatory and autoimmune diseases, biologicals have revolutionized the treatment of several immune-mediated disorders. Biologicals have also been tested in allergic disorders. These include agents targeting IgE; T helper 2 (Th2)-type and Th2-promoting cytokines, including interleukin-4 (IL-4), IL-5, IL-9, IL-13, IL-31 and thymic stromal lymphopoietin (TSLP); pro-inflammatory cytokines, such as IL-1β, IL-12, IL-17A, IL-17F, IL-23 and tumor necrosis factor-α (TNF); chemokine receptor CCR4; and lymphocyte surface and adhesion molecules, including CD2, CD11a, CD20, CD25, CD52 and OX40 ligand. In this task force paper of the Interest Group on Biologicals of the European Academy of Allergy and Clinical Immunology we review biologicals that are currently available or tested for the use in various allergic and urticarial pathologies, by providing an overview on their state of development, area of use, adverse events, and future research directions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Allergic Rhinitis ; Asthma ; Atopic Dermatitis ; Eosinophilic Disorders ; Food Allergy ; Hymenoptera Allergy ; Urticaria; Churg-strauss-syndrome; Severe Atopic-dermatitis; Placebo-controlled Trial; Necrosis-factor-alpha; Chronic Autoimmune Urticaria; Severe Persistent Asthma; Anti-cd20 Rituximab Treatment; Antiimmunoglobulin-e Therapy; Adaptive Immune-responses; Induced Airway Responses
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 70, Issue: 7, Pages: 727-754 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)