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Air pollution from road traffic and systemic inflammation in adults: A cross-sectional analysis in the European ESCAPE project.
Environ. Health Perspect. 123, 785-791 (2015)
BACKGROUND: Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. OBJECTIVES: This study evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease. METHODS: Six cohorts of adults from Central and Northern Europe were used in this cross-sectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation, high-sensitive C-reactive protein (CRP) and fibrinogen, were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants' long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure. RESULTS: Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (>10,000 vehicles/day) road had elevated CRP values (10.2%, 95% CI 2.4-18.8%, compared to persons living in a quiet residential street with less than 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%, 95% CI 0.3-6.1 per 20 µg/m(3)), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed. CONCLUSIONS: Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2015
HGF-reported in Year
2015
ISSN (print) / ISBN
0091-6765
e-ISSN
1552-9924
Quellenangaben
Volume: 123,
Issue: 8,
Pages: 785-791
Publisher
Research Triangle Park
Publishing Place
NC [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504000-001
G-504090-001
G-504090-001
PubMed ID
25816055
WOS ID
WOS:000360693100020
Scopus ID
84938334598
Erfassungsdatum
2015-04-15