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Lanki, T.* ; Hampel, R. ; Tiittanen, P.* ; Andrich, S.* ; Beelen, R.* ; Brunekreef, B.* ; Dratva, J.* ; de Faire, U.* ; Fuks, K.B.* ; Hoffman, B.* ; Imboden, M.* ; Jousilahti, P.* ; Koenig, W.* ; Mahabadi, A.A.* ; Künzli, N.* ; Pedersen, N.L.* ; Penell, J.* ; Pershagen, G.* ; Probst-Hensch, N.M.* ; Schaffner, E.* ; Schindler, C.* ; Sugiri, D.* ; Swart, W.J.* ; Tsai, M.Y.* ; Turunen, A.W.* ; Weinmayr, G.* ; Wolf, K. ; Yli-Tuomi, T.* ; Peters, A.

Air pollution from road traffic and systemic inflammation in adults: A cross-sectional analysis in the European ESCAPE project.

Environ. Health Perspect. 123, 785-791 (2015)
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BACKGROUND: Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. OBJECTIVES: This study evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease. METHODS: Six cohorts of adults from Central and Northern Europe were used in this cross-sectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation, high-sensitive C-reactive protein (CRP) and fibrinogen, were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants' long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure. RESULTS: Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (>10,000 vehicles/day) road had elevated CRP values (10.2%, 95% CI 2.4-18.8%, compared to persons living in a quiet residential street with less than 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%, 95% CI 0.3-6.1 per 20 µg/m(3)), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed. CONCLUSIONS: Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Journal Environmental Health Perspectives
Quellenangaben Volume: 123, Issue: 8, Pages: 785-791 Article Number: , Supplement: ,
Publisher Research Triangle Park
Publishing Place NC [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)