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Filser, J.G. ; Artati, A. ; Li, Q. ; Pütz, C. ; Semder, B. ; Klein, D. ; Kessler, W.

Novel and existing data for a future physiological toxicokinetic model of ethylene and its metabolite ethylene oxide in mouse, rat and human.

Chem. Biol. Interact. 241, 76-86 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The olefin ethylene is a ubiquitously found gas. It originates predominantly from plants, combustion processes and industrial sources. In mammals, inhaled ethylene is metabolized by cytochrome P450-dependent monooxygenases, particularly by cytochrome P450 2E1, to ethylene oxide, an epoxide that directly alkylates proteins and DNA. Ethylene oxide was mutagenic in vitro and in vivo in insects and mammals and carcinogenic in rats and mice. A physiological toxicokinetic model is a most useful tool for estimating the ethylene oxide burden in ethylene-exposed rodents and humans. The only published physiological toxicokinetic model for ethylene and metabolically produced ethylene oxide is discussed. Additionally, existing data required for the development of a future model and for testing its predictive accuracy are reviewed and extended by new gas uptake studies with ethylene and ethylene oxide in B6C3F1 mice and with ethylene in F344 rats.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ethylene ; Ethylene Oxide ; Human ; Mouse ; Rat
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0009-2797
e-ISSN 1872-7786
Journal Chemico-Biological Interactions
Quellenangaben Volume: 241, Issue: , Pages: 76-86 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505200-002
PubMed ID 25868680
DOI 10.1016/j.cbi.2015.04.002
WOS ID WOS:000366951800010
Scopus ID 84947495900
Scopus ID 84928743986
Erfassungsdatum 2015-04-16
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