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Open Access Green as soon as Postprint is submitted to ZB.
Novel and existing data for a future physiological toxicokinetic model of ethylene and its metabolite ethylene oxide in mouse, rat and human.
Chem. Biol. Interact. 241, 76-86 (2015)
The olefin ethylene is a ubiquitously found gas. It originates predominantly from plants, combustion processes and industrial sources. In mammals, inhaled ethylene is metabolized by cytochrome P450-dependent monooxygenases, particularly by cytochrome P450 2E1, to ethylene oxide, an epoxide that directly alkylates proteins and DNA. Ethylene oxide was mutagenic in vitro and in vivo in insects and mammals and carcinogenic in rats and mice. A physiological toxicokinetic model is a most useful tool for estimating the ethylene oxide burden in ethylene-exposed rodents and humans. The only published physiological toxicokinetic model for ethylene and metabolically produced ethylene oxide is discussed. Additionally, existing data required for the development of a future model and for testing its predictive accuracy are reviewed and extended by new gas uptake studies with ethylene and ethylene oxide in B6C3F1 mice and with ethylene in F344 rats.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ethylene ; Ethylene Oxide ; Human ; Mouse ; Rat
ISSN (print) / ISBN
0009-2797
e-ISSN
1872-7786
Journal
Chemico-Biological Interactions
Quellenangaben
Volume: 241,
Pages: 76-86
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed