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Helmbrecht, M.S. ; Soellner, H. ; Castiblanco-Urbina, M.A. ; Winzeck, S. ; Sundermeier, J. ; Theis, F.J. ; Fouad, K.* ; Huber, A.B.

A critical period for postnatal adaptive plasticity in a model of motor axon miswiring.

PLoS ONE 10:e0123643 (2015)
Publ. Version/Full Text DOI PMC
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The correct wiring of neuronal circuits is of crucial importance for precise neuromuscular functionality. Therefore, guidance cues provide tight spatiotemporal control of axon growth and guidance. Mice lacking the guidance cue Semaphorin 3F (Sema3F) display very specific axon wiring deficits of motor neurons in the medial aspect of the lateral motor column (LMCm). While these deficits have been investigated extensively during embryonic development, it remained unclear how Sema3F mutant mice cope with these errors postnatally. We therefore investigated whether these animals provide a suitable model for the exploration of adaptive plasticity in a system of miswired neuronal circuitry. We show that the embryonically developed wiring deficits in Sema3F mutants persist until adulthood. As a consequence, these mutants display impairments in motor coordination that improve during normal postnatal development, but never reach wildtype levels. These improvements in motor coordination were boosted to wildtype levels by housing the animals in an enriched environment starting at birth. In contrast, a delayed start of enriched environment housing, at 4 weeks after birth, did not similarly affect motor performance of Sema3F mutants. These results, which are corroborated by neuroanatomical analyses, suggest a critical period for adaptive plasticity in neuromuscular circuitry. Interestingly, the formation of perineuronal nets, which are known to close the critical period for plastic changes in other systems, was not altered between the different housing groups. However, we found significant changes in the number of excitatory synapses on limb innervating motor neurons. Thus, we propose that during the early postnatal phase, when perineuronal nets have not yet been formed around spinal motor neurons, housing in enriched environment conditions induces adaptive plasticity in the motor system by the formation of additional synaptic contacts, in order to compensate for coordination deficits.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Visual-cortex; Spinal-cord; Environmental Enrichment; Dependent Plasticity; Extracellular-matrix; Semaphorin 3f; Guidance; Experience; Neurons; System
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 10, Issue: 4, Pages: , Article Number: e0123643 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Computational Biology (ICB)
POF-Topic(s) 30204 - Cell Programming and Repair
30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-500500-001
G-503800-001
G-500592-001
PubMed ID 25874621
DOI 10.1371/journal.pone.0123643
WOS ID WOS:000352845100193
Scopus ID 84928815177
Erfassungsdatum 2015-04-17
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