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Müller, T.D. ; Nogueiras, R.A.* ; Andermann, M.L.* ; Andrews, Z.B.* ; Anker, S.D.* ; Argente, J.* ; Batterham, R.* ; Benoit, S.C.* ; Bowers, C.Y.* ; Broglio, F.* ; Casanueva, F.F.F.* ; D'Alessio, D.* ; Depoortere, I.* ; Geliebter, A.A.* ; Ghigo, E.* ; Cole, P.A.* ; Cowley, M.A.* ; Cummings, D.E.* ; Dagher, A.* ; Diano, S.* ; Dickson, S.L.* ; Dieguez, C.* ; Granata, R.* ; Grill, H.J.* ; Grove, K.L.* ; Habegger, K.M.* ; Heppner, K.M.* ; Heiman, M.L.* ; Holsen, L.* ; Holst, B.* ; Inui, A.* ; Jansson, J.O.* ; Kirchner, H.* ; Korbonits, M.* ; Laferrère, B.* ; LeRoux, C.W.* ; López, M.D.* ; Morin, S. ; Nakazato, M.* ; Nass, R.* ; Perez-Tilve, D.* ; Pfluger, P.T. ; Schwartz, T.W.* ; Seeley, R.J.* ; Sleeman, M.W.* ; Sun, Y.* ; Sussel, L.* ; Tong, J.* ; Thorner, M.O.* ; van der Lely, A.J.* ; van der Ploeg, L.H.T.* ; Zigman, J.M.* ; Kojima, M.* ; Kangawa, K.* ; Smith, R.G.* ; Horvath, T.* ; Tschöp, M.H.

Ghrelin.

Mol. Metab. 4, 437–460 (2015)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Ghrelin ; Growth Hormone Segretagogue Receptor
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Journal Molecular Metabolism
Quellenangaben Volume: 4, Issue: 6, Pages: 437–460 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)