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Möbs, C.* ; Müller, J.* ; Rudzio, A.* ; Pickert, J.* ; Blank, S. ; Jakob, T.* ; Spillner, E.* ; Pfützner, W.*

Decline of Ves v 5-specific blocking capacity in wasp venom-allergic patients after stopping allergen immunotherapy.

Allergy 70, 715-719 (2015)

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Open Access Green as soon as Postprint is submitted to ZB.

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While allergen-specific immunotherapy (AIT) is very efficient in hymenoptera venom (HV)-allergic patients, long-term outcome after finishing AIT is not well investigated, especially regarding mechanisms that are suggested to contribute to allergen-specific tolerance. Here, we analyse the Ves v 5-inhibitory activity of sera from wasp venom-allergic patients using the novel cell-free enzyme-linked immunosorbent facilitated antigen binding (ELIFAB) assay. Compared to pre-AIT, sera from patients undergoing AIT displayed an increased ability to inhibit Ves v 5 binding by IgE antibodies. In contrast, this inhibitory activity was reduced in patients having finished AIT 5-12 years ago. Allergen-blocking capacity correlated with serum concentrations of Ves v 5-specific IgG4 which rose during AIT but almost reached pretreatment levels in patients who had stopped AIT more than 5 years ago. These data raise questions about how long allergen tolerance is maintained in AIT-treated HV-allergic patients and suggest that the ELIFAB assay might be an easy-to-use tool assessing long-term tolerance in patients treated with HV-AIT.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Igg ; Allergen-specific Immunotherapy ; Blocking Antibodies ; Enzyme-linked Immunosorbent Facilitated Antigen Binding ; Insect Venom; Long-term Protection; Bee Venom; Pollen Immunotherapy; Antibody-responses; Ige Binding; Inhibition; Severity; Stings

ISSN (print) / ISBN 0105-4538

e-ISSN 1398-9995

Journal Allergy

Quellenangaben Volume: 70, Issue: 6, Pages: 715-719

Publisher Wiley

Publishing Place Hoboken

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute for Allergy Research (IAF)