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Ferrari, U. ; Künzel, H.E.* ; Tröndle, K. ; Rottenkolber, M.* ; Kohn, D.* ; Fugmann, M. ; Banning, F. ; Weise, M. ; Sacco, V. ; Hasbargen, U.* ; Hutter, S.* ; Parhofer, K.G. ; Kloiber, S.* ; Ising, M.* ; Seissler, J. ; Lechner, A.

Poor sleep quality is associated with impaired glucose tolerance in women after gestational diabetes.

J. Psychiatr. Res. 65, 166-171 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We analyzed the association of sleep quality and glucose metabolism in women after gestational diabetes (pGDM) and in women after normoglycemic pregnancy (controls). Data during pregnancy and a visit within the first 15 months after delivery were collected from 61 pGDM and 30 controls in a prospective cohort study. This included a medical history, physical examination, questionnaires (Pittsburgh Sleep Quality Index (PSQI), and Perceived Stress Scale (PSS)), and 5-point oral glucose tolerance test with insulin measurements to determine indices of insulin sensitivity and insulin secretion. We used Spearman correlation coefficients and multivariate regression models for analysis.9.3 ± 3.2 months after delivery, pGDM had significantly higher fasting and 2 h glucose levels and lower insulin sensitivity than controls. There was no significant difference in age, BMI and sleep quality as assessed with the PSQI between the two groups. The PSQI score correlated with the ogtt-2 h plasma glucose in pGDM (δ = 0.41; p = 0.0012), but not in controls. This association was confirmed with a multivariate linear regression model with adjustment for age, BMI and months post-delivery. Perceived stress was an independent risk factor (OR 1.12; 95% CI 1.02-1.23) for impaired sleep. Our findings suggest that post-delivery sleep quality significantly influences glucose tolerance in women after GDM and that impaired sleep is associated with increased stress perception. Measures to improve of sleep quality and reduce perceived stress should therefore be tested as additional strategies to prevent progression to type 2 diabetes after GDM.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gestational Diabetes ; Glucose Tolerance ; Perceived Stress ; Sleep Quality; Pituitary-adrenal Axis; Insulin-resistance; Risk; Obesity; Mellitus; Disturbances; Sensitivity; Pregnancy; Duration; Insomnia
ISSN (print) / ISBN 0022-3956
e-ISSN 1879-1379
Journal Journal of Psychiatric Research
Quellenangaben Volume: 65, Issue: , Pages: 166-171 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Oxford
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CCG Biomarker for the subclassification of T2DM (KKG-KDB)
CCG Nutrigenomics and Type 2 Diabetes (KKG-KDN)