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Open Access Green as soon as Postprint is submitted to ZB.
MSX1-induced neural crest-like reprograming promotes melanoma progression.
J. Invest. Dermatol. 135, S111 (2015)
Melanoma cells share many biological properties with neural crest cells. Here, we show that the homeodomain transcription factor Msh homeobox 1 (MSX1), which is essential for neural crest specification, reprograms melanocytes towards a neural crest precursor-like state. MSX1-reprogrammed melanocytes express the neural crest marker p75 and are able to differentiate into neuronal and mesenchymal lineages. Mechanistically, MSX1 suppresses the proximal promoter of microphthalmia-associated transcription factor (MITF), the master transcriptional regulator of melanogenesis. MSX1 expression is also significantly correlated with melanoma progression. MSX1 prompts melanoma cell motility and depletion of MSX1 significantly inhibits melanoma metastasis. These results demonstrate that not only can neural crest-like reprogramming in melanocytes be achieved by a single factor, but also that similar dedifferentiation is a critical process for melanoma progression.
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Publication type
Article: Journal article
Document type
Meeting abstract
ISSN (print) / ISBN
0022-202X
e-ISSN
1523-1747
Conference Title
AACR Special Conference on Advances in Melanoma: From Biology to Therapy
Conference Date
20-23 September 2014
Conference Location
Philadelphia, PA, USA
Quellenangaben
Volume: 135,
Pages: S111
Publisher
Elsevier
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)