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Zhao, X.J.* ; Hoheisel, G.* ; Schauer, J.* ; Bornstein, S.R.*

Corticotropin-releasing hormone-binding protein and its possible role in neuroendocrinological research.

Horm. Metab. Res. 29, 373-378 (1997)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Corticotropin-releasing hormone-binding protein (CRH-BP), predominately produced by the liver, is a glycoprotein with a molecular weight of 37 kDa. The mature protein consists of 7 exons and 6 introns, with 5 tandem disulfide bridges which are essential for the binding of corticotropin-releasing hormone (CRH). This binding protein is distributed and expressed differently from corticotropin-releasing hormone receptors (CRH-Rs), as is the ligand requirement. Most CRH in plasma is bound to its binding protein, is therefore inactive and unable to bind to its receptor. Other competitives can reverse the binding, liberating CRH. Together with the CRH neuropeptides and CRH receptors, CRH-binding protein plays a role in the hypothalamic-pituitary-adrenal axis, in immune/inflammatory reactions as an auto/paracrine proinflammatory regulator, in pregnancy, as well as in some pathological conditions.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 1997
HGF-reported in Year 0
ISSN (print) / ISBN 0018-5043
e-ISSN 1439-4286
Journal Hormone and Metabolic Research
Quellenangaben Volume: 29, Issue: 8, Pages: 373-378 Article Number: , Supplement: ,
Publisher Thieme
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
PubMed ID 9288573
DOI 10.1055/s-2007-979058
Erfassungsdatum 1997-12-31
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