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Open Access Green as soon as Postprint is submitted to ZB.
Expression of interleukin-1 in human pheochromocytoma.
J. Endocrinol. Invest. 19, 693-698 (1996)
Cytokines and in particular interleukin 1 (IL-1) play a role in the micro-environment of various tumors. In addition, it is well established that IL-1 is a neurotrophic, angiogenetic and fibrogenetic factor. Using in situ hybridization we analyzed the expression of endogenous IL-1 in human pheochromocytoma (PCC). With the help of specific antibodies to B- and T-cells, macrophages, and neuroendocrine cell antigens, we characterized the distribution and localization of various cell types in human PCC. The combination of immunohistochemistry and in situ hybridization was eminently suited to defining the exact cellular source of IL-1 expression. In situ hybridization and immunostaining revealed that IL-1 mRNA was located primarily in the tumor cell itself. IL-1 may therefore constitute an important paracrine/autocrine factor in neuroendocrine tumors.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
1996
HGF-reported in Year
0
ISSN (print) / ISBN
0391-4097
e-ISSN
1720-8386
Quellenangaben
Volume: 19,
Issue: 10,
Pages: 693-698
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
9007702
Erfassungsdatum
1996-12-31