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Dean-Ben, X.L. ; Fehm, T.F.* ; Gostic, M.* ; Razansky, D.

Volumetric hand-held optoacoustic angiography as a tool for real-time screening of dense breast.

J. Biophotonics 9, 253-259 (2016)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Existing mammographic screening solutions are generally associated with several major drawbacks, such as exposure to ionizing radiation or insufficient sensitivity in younger populations with radiographically-dense breast. Even when combined with ultrasound or magnetic resonance imaging, X-Ray mammography may still attain unspecific or false positive results. Thus, development of new breast imaging tools represents a timely medical challenge. We report on a new approach to high-resolution functional and anatomical breast angiography using volumetric hand-held optoacoustic tomography, which employs light intensities safe for human use. Experiments in young healthy volunteers with fibroglandular-dominated dense breasts revealed the feasibility of rendering three-dimensional images representing vascular anatomy and functional blood oxygenation parameters at video rate. Sufficient contrast was achieved at depths beyond 2 cm within dense breasts without compromising the real-time imaging performance. The suggested solution may thus find applicability as a standalone or supplemental screening tool for early detection and follow-up of carcinomas in radiographically-dense breasts. Volumetric handheld optoacoustic tomography scanner uses safe pulses of near-infrared light to render three-dimensional images of deep vascular anatomy, blood oxygenation and breast parenchyma at video rate.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Breast Screening ; Clinical Translation ; Hand-held Scanner ; Optoacoustic Tomography ; Photoacoustic Imaging; Cancer; Tomography; Mammography; Mri; Angiogenesis; Vasculature; Mortality; Therapy; Risk
ISSN (print) / ISBN 1864-063X
e-ISSN 1864-0648
Journal Journal of Biophotonics
Quellenangaben Volume: 9, Issue: 3, Pages: 253-259 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)