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Dean-Ben, X.L. ; Fehm, T.F.* ; Gostic, M.* ; Razansky, D.

Volumetric hand-held optoacoustic angiography as a tool for real-time screening of dense breast.

J. Biophotonics 9, 253-259 (2016)

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Open Access Green as soon as Postprint is submitted to ZB.

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Existing mammographic screening solutions are generally associated with several major drawbacks, such as exposure to ionizing radiation or insufficient sensitivity in younger populations with radiographically-dense breast. Even when combined with ultrasound or magnetic resonance imaging, X-Ray mammography may still attain unspecific or false positive results. Thus, development of new breast imaging tools represents a timely medical challenge. We report on a new approach to high-resolution functional and anatomical breast angiography using volumetric hand-held optoacoustic tomography, which employs light intensities safe for human use. Experiments in young healthy volunteers with fibroglandular-dominated dense breasts revealed the feasibility of rendering three-dimensional images representing vascular anatomy and functional blood oxygenation parameters at video rate. Sufficient contrast was achieved at depths beyond 2 cm within dense breasts without compromising the real-time imaging performance. The suggested solution may thus find applicability as a standalone or supplemental screening tool for early detection and follow-up of carcinomas in radiographically-dense breasts. Volumetric handheld optoacoustic tomography scanner uses safe pulses of near-infrared light to render three-dimensional images of deep vascular anatomy, blood oxygenation and breast parenchyma at video rate.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Breast Screening ; Clinical Translation ; Hand-held Scanner ; Optoacoustic Tomography ; Photoacoustic Imaging; Cancer; Tomography; Mammography; Mri; Angiogenesis; Vasculature; Mortality; Therapy; Risk

ISSN (print) / ISBN 1864-063X

e-ISSN 1864-0648

Journal Journal of Biophotonics

Quellenangaben Volume: 9, Issue: 3, Pages: 253-259

Publisher Wiley

Publishing Place Weinheim

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)