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Open Access Green as soon as Postprint is submitted to ZB.
RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing.
Nanoscale 7, 9083-9091 (2015)
Gold glyconanoparticles (GlycoNPs) are full of promise in areas like biomedicine, biotechnology and materials science due to their amazing physical, chemical and biological properties. Here, siRNA GlycoNPs (AuNP@PEG@Glucose@siRNA) in comparison with PEGylated GlycoNPs (AuNP@PEG@Glucose) were applied in vitro to a luciferase-CMT/167 adenocarcinoma cancer cell line and in vivo via intratracheal instillation directly into the lungs of B6 albino mice grafted with luciferase-CMT/167 adenocarcinoma cells. siRNA GlycoNPs but not PEGylated GlycoNPs induced the expression of pro-apoptotic proteins such as Fas/CD95 and caspases 3 and 9 in CMT/167 adenocarcinoma cells in a dose dependent manner, independent of the inflammatory response, evaluated by bronchoalveolar lavage cell counting. Moreover, in vivo pulmonary delivered siRNA GlycoNPs were capable of targeting c-Myc gene expression (a crucial regulator of cell proliferation and apoptosis) via in vivo RNAi in tumour tissue, leading to an ∼80% reduction in tumour size without associated inflammation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Human-endothelial Cells; Gold Nanoparticles; Carbohydrate Interactions; Dna-damage; C-myc; Glycolysis; Exposure; Models; Tools; Death
ISSN (print) / ISBN
2040-3364
e-ISSN
2040-3372
Journal
Nanoscale
Quellenangaben
Volume: 7,
Issue: 19,
Pages: 9083-9091
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)