PuSH - Publication Server of Helmholtz Zentrum München: HBV-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro.

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Hoh, A.* ; Heeg, M.* ; Ni, Y.* ; Schuch, A.* ; Binder, B.* ; Hennecke, N.* ; Blum, H.E.* ; Nassal, M.* ; Protzer, U. ; Hofmann, M.* ; Urban, S.* ; Thimme, R.*

HBV-infected HepG2^hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8⁺ T cells in vitro.

J. Virol. 89, 7433-7438 (2015)

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CD8(+) T cells are main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems such as low infection rates restricted mechanistic studies of HBV-specific CD8(+) T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2(hNTCP) cells that endogenously processed and presented viral antigens to HBV-specific CD8(+) T cells. This induced cytolytic and non-cytolytic CD8(+) T-cell effector functions and reduction of viral loads.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Viral Clearance; Hepatocytes; Lymphocytes; Expression; Lines; Vivo

ISSN (print) / ISBN 0022-538X

e-ISSN 1098-5514

Journal Journal of Virology

Quellenangaben Volume: 89, Issue: 14, Pages: 7433-7438

Publisher American Society for Microbiology (ASM)

Publishing Place Washington

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)