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Open Access Green as soon as Postprint is submitted to ZB.
Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain.
Science 348, 789-793 (2015)
Adult neural stem cells are the source for restoring injured brain tissue. We used repetitive imaging to follow single stem cells in the intact and injured adult zebrafish telencephalon in vivo and found that neurons are generated by both direct conversions of stem cells into postmitotic neurons and via intermediate progenitors amplifying the neuronal output. We observed an imbalance of direct conversion consuming the stem cells and asymmetric and symmetric self-renewing divisions, leading to depletion of stem cells over time. After brain injury, neuronal progenitors are recruited to the injury site. These progenitors are generated by symmetric divisions that deplete the pool of stem cells, a mode of neurogenesis absent in the intact telencephalon. Our analysis revealed changes in the behavior of stem cells underlying generation of additional neurons during regeneration.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Telencephalon; Regeneration; Neurogenesis; Differentiation; Quiescence; Forebrain; Model; Zone
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 348,
Issue: 6236,
Pages: 789-793
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
Washington
Non-patent literature
Publications
Reviewing status
Peer reviewed