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Glutathione peroxidase 4 (Gpx4) and ferroptosis: What's so special about it?
Mol. Cell. Oncol. 2:e995047 (2015)
The system XC−/glutathione/glutathione peroxidase 4 axis pivotally controls ferroptosis, a recently described form of regulated, non-apoptotic cell death. Compelling evidence established that this cell death route is of high relevance not only for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cell death; Lipid peroxidation; Non-apoptotic cell death; Regulated necrosis
e-ISSN
2372-3556
Journal
Molecular & Cellular Oncology
Quellenangaben
Volume: 2,
Issue: 3,
Article Number: e995047
Publisher
Taylor & Francis
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)