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Greiter, M. ; Keck, L. ; Siegmund, T.* ; Hoeschen, C. ; Oeh, U. ; Paretzke, H.G.

Differences in exhaled gas profiles between patients with type 2 diabetes and healthy controls.

Diabetes Technol. Ther. 12, 455-463 (2010)

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Open Access Green as soon as Postprint is submitted to ZB.

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AIMS: Recent advances in analytical technology allow the detection of several hundred volatile organic compounds (VOCs) in human exhaled air, many of which reflect unidentified endogenous pathways. This study was performed to determine whether a breath gas analysis using proton transfer reaction-mass spectrometry (PTR-MS) could serve as a noninvasive method to distinguish between patients with type 2 diabetes mellitus and healthy controls. METHODS: Breath and room air samples were measured from 21 patients with insulin-treated type 2 diabetes and 26 healthy controls. VOCs in the mass range of 20-200 atomic mass units were analyzed using PTR-MS. RESULTS: We identified eight masses characteristic of endogenous VOCs that showed significant differences in the gas profiles of patients with type 2 diabetes and healthy control subjects. Using these VOCs for linear discriminant analysis, the sensitivity and specificity were found to be 90% and 92%, respectively. CONCLUSIONS: These results suggest that it is possible to separate patients with diabetes mellitus type 2 from healthy controls by multivariate analysis of exhaled endogenous VOCs. This is a first step towards the development of a noninvasive test using breath gas of at-risk persons and making it an attractive option for large-scale testing of at-risk populations. However, the establishment of exhaled volatiles as metabolic markers requires additional confirmatory investigations.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Reaction-mass-spectrometry; Colatile organic-compounds; PTR-MS; Human breath; Medical applications; Air; Acetone; Tube; Isoprene; Propanol

ISSN (print) / ISBN 1520-9156

e-ISSN 1557-8593

Journal Diabetes Technology & Therapeutics

Quellenangaben Volume: 12, Issue: 6, Pages: 455-463

Publisher Mary Ann Liebert

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Medical Radiation Physics and Diagnostics (AMSD)