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Choi, S.S.* ; Mandelis, A.* ; Guo, X.* ; Lashkari, B.* ; Kellnberger, S. ; Ntziachristos, V.

Wavelength-Modulated Differential Photoacoustic Spectroscopy (WM-DPAS) for noninvasive early cancer detection and tissue hypoxia monitoring.

J. Biophotonics 9, 388-395 (2016)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
This study introduces a novel noninvasive differential photoacoustic method, Wavelength Modulated Differential Photoacoustic Spectroscopy (WM-DPAS), for noninvasive early cancer detection and continuous hypoxia monitoring through ultrasensitive measurements of hemoglobin oxygenation levels (StO2 ). Unlike conventional photoacoustic spectroscopy, WM-DPAS measures simultaneously two signals induced from square-wave modulated laser beams at two different wavelengths where the absorption difference between maximum deoxy- and oxy-hemoglobin is 680 nm, and minimum (zero) 808 nm (the isosbestic point). The two-wavelength measurement efficiently suppresses background, greatly enhances the signal to noise ratio and thus enables WM-DPAS to detect very small changes in total hemoglobin concentration (CHb ) and oxygenation levels, thereby identifying pre-malignant tumors before they are anatomically apparent. The non-invasive nature also makes WM-DPAS the best candidate for ICU bedside hypoxia monitoring in stroke patients. Sensitivity tunability is another special feature of the technology: WM-DPAS can be tuned for different applications such as quick cancer screening and accurate StO2 quantification by selecting a pair of parameters, signal amplitude ratio and phase shift. The WM-DPAS theory has been validated with sheep blood phantom measurements. Sensitivity comparison between conventional single-ended signal and differential signal.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biosensor ; Differential Photoacoustic ; Hypoxia ; Noninvasive ; Premalignant; Tumor Hypoxia; Hemoglobin Concentration; Oxygen-saturation; Breast-tissue; Quantification; Tomography
ISSN (print) / ISBN 1864-063X
e-ISSN 1864-0648
Journal Journal of Biophotonics
Quellenangaben Volume: 9, Issue: 4, Pages: 388-395 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)