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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes.
Hepatology 59, 713-723 (2014)
Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are all strongly associated and are all reaching epidemic proportions. Whether there is a causal link between NAFLD and hepatic insulin resistance is controversial. This review will discuss recent studies in both humans and animal models of NAFLD that have implicated increases in hepatic diacylglycerol (DAG) content leading to activation of novel protein kinase Cϵ (PKCϵ) resulting in decreased insulin signaling in the pathogenesis of NAFLD-associated hepatic insulin resistance and type 2 diabetes. The DAG-PKCϵ hypothesis can explain the occurrence of hepatic insulin resistance observed in most cases of NAFLD associated with obesity, lipodystrophy, and type 2 diabetes.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0270-9139
e-ISSN
1527-3350
Journal
Hepatology
Quellenangaben
Volume: 59,
Issue: 2,
Pages: 713-723
Publisher
Wiley
Publishing Place
Hoboken, NJ
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)