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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
The role of INDY in metabolic regulation.
Comp. Struc. Biotech. J. 6:e201303020 (2013)
Reduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc 3a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ß-oxidation. This review will provide an overview on different mammalian SLC 3 family members with a focus on mINDY (SLC 3A5) in glucose and energy metabolism and will highlight the role of mINDY as a putative therapeutic target for the treatment of obesity, non-alcoholic fatty liver disease and type 2 diabetes.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Indy ; Citrate ; Diabetes ; Insulin Resistance ; Longevity ; Obesity
ISSN (print) / ISBN
2001-0370
e-ISSN
2001-0370
Quellenangaben
Volume: 6,
Article Number: e201303020
Publisher
Research Network of Computational and Structural Biotechnology (RNCSB)
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)