PuSH - Publication Server of Helmholtz Zentrum München

Shaaban, R.* ; Leynaert, B.* ; Soussan, D.* ; Antò, J.M.* ; Chinn, S.* ; de Marco, R.* ; Garcia-Aymerich, J.* ; Heinrich, J. ; Janson, C.* ; Jarvis, D.* ; Sunyer, J.* ; Svanes, C.* ; Wjst, M. ; Burney, P.G.* ; Neukirch, F.* ; Zureik, M.*

Physical activity and bronchial hyperresponsiveness: European Community Respiratory Health Survey II.

Thorax 62, 403-410 (2007)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Identification of the risk factors for bronchial hyperresponsiveness (BHR) would increase the understanding of the causes of asthma. The relationship between physical activity and BHR in men and women aged 28.0-56.5 years randomly selected from 24 centres in 11 countries participating in the European Community Respiratory Health Survey II was investigated. METHODS: 5158 subjects answered questionnaires about physical activity and performed BHR tests. Participants were asked about the frequency and duration of usual weekly exercise resulting in breathlessness or sweating. BHR was defined as a decrease in forced expiratory volume in 1 s of at least 20% of its post-saline value for a maximum methacholine dose of 2 mg. RESULTS: Both frequency and duration of physical activity were inversely related to BHR. The prevalence of BHR in subjects exercising or=4 times a week was 14.5%, 11.6% and 10.9%, respectively (p<0.001). The corresponding odds ratios were 1.00, 0.78 (95% CI 0.62 to 0.99) and 0.69 (95% CI 0.50 to 0.94) after controlling for potential confounding factors. The frequency of BHR in subjects exercising <1 h, 1-3 h and >or=4 h a week was 15.9%, 10.9% and 10.7%, respectively (p<0.001). The corresponding adjusted odds ratios were 1.00, 0.70 (95% CI 0.57 to 0.87) and 0.67 (95% CI 0.50 to 0.90). Physical activity was associated with BHR in all studied subgroups. CONCLUSIONS: These results suggest that BHR is strongly and independently associated with decreased physical activity. Further studies are needed to determine the mechanisms underlying this association.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords lung-function; risk-factors; airway hyperresponsiveness; deep inspiration; high prevalence; follow-up; asthma; responsiveness; exercise; population
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Journal Thorax
Quellenangaben Volume: 62, Issue: 5, Pages: 403-410 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)