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Open Access Green as soon as Postprint is submitted to ZB.
Lymphoid progenitors as candidate cancer stem cells in AML: New perspectives.
Cell Cycle 6, 543-545 (2007)
Mouse models have demonstrated that both hematopoietic stem cells (HSCs) as well as downstream myeloid progenitors can be targets of transformation in AML. We recently showed in a murine model of the CALM/AF10 fusion gene positive leukemia, that progenitors with lymphoid characteristics can be leukemic stem cell (LSC) candidates in AML. We could demonstrate that the LSC candidate in the CALM/AF10 murine model was positive for the lymphoid associated surface antigen B220, which was not expressed by the leukemic bulk or the normal HSC pool. This offers the intriguing possibility to target the LSCs with antibodies that spare the normal stem cell.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CALM/AF10; leukemic stem cells; AML; targeted therapy
Language
english
Publication Year
2007
HGF-reported in Year
0
ISSN (print) / ISBN
1538-4101
e-ISSN
1551-4005
Journal
Cell Cycle
Quellenangaben
Volume: 6,
Issue: 5,
Pages: 543-545
Publisher
Landes Bioscience
Reviewing status
Peer reviewed
Institute(s)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-521000-001
Erfassungsdatum
2007-11-08